Sodium borohydride → HCID 10756510、化合物

HRID 235199ノート

反応式

HRID 235199 の反応式
[C:1]1([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:12][CH:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+]>CO>[OH:9][CH:8]([C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:14][CH:15]=1)[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 10709050HCID 10709050、化合物

生成物 1

HCID 10756510HCID 10756510、化合物収率 100.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a suspension of 20.0 g of methyl 4-[4-(phenylacetyl)phenyl]butyrate in 200 ml of methanol, 2.52 g of sodium borohydride was added portionwise under ice-cooling, and stirring was continued for 1 hour. After the reaction solvent was removed under reduced pressure, the residue was added with water and then extracted with ether. After the ether layer was washed with water and dried, the solvent was removed to yield 20.3 g of pale yellow oil.

後処理

  1. additionwas added portionwise under ice-
  2. temperaturecooling
  3. customAfter the reaction solvent was removed under reduced pressure
  4. additionthe residue was added with water
  5. extractionextracted with ether
  6. washAfter the ether layer was washed with water
  7. customdried
  8. customthe solvent was removed

出典と根拠

ORDレコード
ord-4d93a87cc39344ffbe9de88a23eceed3
出典データセット
uspto-grants-1997_01
特許番号
US05597848

反応ノート

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