3-Acetylindole → 3-(dimethylamino)-1-(1H-indol-3-yl)prop-2-en-1-one
反応式
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1)(=[O:3])[CH3:2].C(O[CH:18](N(C)C)[N:19]([CH3:21])[CH3:20])(C)(C)C>>[CH3:18][N:19]([CH3:21])[CH:20]=[CH:2][C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1)=[O:3]参加物
3
実験手順
A mixture of 3.18 g of 3-acetylindole and 5.17 ml. (4.36 g) of tert-butoxybis(dimethylamino)methane was heated on a steam bath for 4 hours. The cooled reaction mixture was triturated with n-hexanes and gave a semisolid. The solvent was removed in vacuo and the material was triturated with dichloromethane giving 3.08 g of the desired compound as a tan crystalline solid, mp 239°-245° C.,
後処理
- customThe cooled reaction mixture
- customwas triturated with n-hexanes
- customgave a semisolid
- customThe solvent was removed in vacuo
- customthe material was triturated with dichloromethane giving 3.08 g of the desired compound as a tan crystalline solid, mp 239°-245° C.
出典と根拠
- ORDレコード
- ord-7f0f9417e9954948a85690c54eaf7679
- 出典データセット
- uspto-grants-1989_10
- 特許番号
- US04876252
反応ノート
読み込み中…