Hexanoic Acid → 4,4-Dimethyl-2-pentyl-4,5-dihydro-1,3-oxazole

反応式

[C:1]([OH:8])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[NH2:9][C:10]([CH3:14])([CH3:13])[CH2:11]O>>[CH3:11][C:10]1([CH3:14])[CH2:13][O:8][C:1]([CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])=[N:9]1

参加物

反応物 2

HCID 8892Hexanoic Acid

HCID 118072-Amino-2-methyl-1-propanol

生成物 1

HCID 123255584,4-Dimethyl-2-pentyl-4,5-dihydro-1,3-oxazole収率 81.2%

反応条件

温度: 185 °C

実験手順

Following the procedure under Example 11, 6.085 g (52.4 mmoles) of hexanoic acid and 10 ml (9.34 g, 104.8 mmoles) of 2-amino-2-methylpropanol was heated to 185°C. Work up and fractional distillation gave 7.2g (81%) of product, b.p. 90°-92° C./25mmHg.

後処理

distillationfractional distillation

出典と根拠

ORDレコード: ord-6cc3f251a01e4e1ab379b4fc718c2f48
出典データセット: uspto-grants-1989_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04876249

反応ノート

読み込み中…

参加物