Sodium borohydride → 7,12-Dioxaspiro[5.6]dodecane-9-methanol

HRID 2353ノート

反応式

HRID 2353 の反応式
[CH:1]([CH:3]1[CH2:14][CH2:13][O:12][C:6]2([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]2)[O:5][CH2:4]1)=[O:2].[BH4-].[Na+]>CO>[OH:2][CH2:1][CH:3]1[CH2:14][CH2:13][O:12][C:6]2([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]2)[O:5][CH2:4]1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 109545329-Formyl-7,12-dioxaspiro[5,6]dodecane

生成物 1

HCID 110308447,12-Dioxaspiro[5.6]dodecane-9-methanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
10 °C

実験手順

To a solution of 9-formyl-7, 12-dioxaspiro[5,6]dodecane of formula IV (5 g) in methanol (15 ml) was added in small portions NaBH4 (0.5 g) while stirring the solution and maintaining the temperature at 10° C. After complete addition, the reaction mixture was stirred for 3 hr at 20° C. The product residue obtained after evaporation of methanol was treated with water (20 ml), extracted into ether and dried over K2CO3. Evaporation of ether gave 9-hydroxymethyl-7, 12-dioxaspiro[5,6]dodecane of formula V (5 g) of the drawings as colorless viscous liquid.

後処理

  1. additionAfter complete addition
  2. stirringthe reaction mixture was stirred for 3 hr at 20° C
  3. customThe product residue obtained
  4. customafter evaporation of methanol
  5. additionwas treated with water (20 ml)
  6. extractionextracted into ether
  7. dry with materialdried over K2CO3
  8. customEvaporation of ether

出典と根拠

ORDレコード
ord-68ed201820eb41f482bf2de3bfa7daba
出典データセット
uspto-grants-1998_03
特許番号
US05728848

反応ノート

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