Ethanolamine → HCID 57418690、化合物
反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([I:11])=[CH:9][N:10]=2)[N:7]=1.[CH2:12]([CH2:14][NH2:15])[OH:13]>>[I:11][C:8]1[N:6]2[N:7]=[C:2]([NH:15][CH2:14][CH2:12][OH:13])[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1参加物
3
実験手順
562 mg (2.0 mmol) of 6-chloro-3-iodoimidazo[1,2-b]pyridazine and 2.35 ml (39.2 mmol) of ethanolamine were stirred at 90° C. for 16 h. After cooling, the mixture was concentrated. The resulting residue was purified by chromatography (DCM/EtOH 9:1). 224 mg of the product were obtained.
後処理
- temperatureAfter cooling
- concentrationthe mixture was concentrated
- customThe resulting residue was purified by chromatography (DCM/EtOH 9:1)
出典と根拠
- ORDレコード
- ord-ffdaf7540f144583955b8582021ceb08
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07750000B2
反応ノート
読み込み中…