Potassium Acetate → ethyl 1-acetyl-4-oxocyclohexane-1-carboxylate

HRID 2353088ノート

反応式

HRID 2353088 の反応式
[C:1]([C:4]([C:15]([O:17][CH2:18][CH3:19])=[O:16])([CH2:10][CH2:11][C:12]([OH:14])=O)[CH2:5][CH2:6]C(O)=O)(=[O:3])[CH3:2].C([O-])(=O)C.[K+]>C(OC(=O)C)(=O)C>[C:1]([C:4]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:5][CH2:6][C:12](=[O:14])[CH2:11][CH2:10]1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 517044Potassium AcetateHCID 27760544-Acetyl-4-(ethoxycarbonyl)heptanedioic acid

生成物 1

HCID 12522245ethyl 1-acetyl-4-oxocyclohexane-1-carboxylate

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

反応条件

温度
145 °C

実験手順

To a stirred suspension of Step 2 product (1 eq) in acetic anhydride (2.5 v/w) under nitrogen was added potassium acetate (0.02 eq). The reaction mixture was heated to, and stirred at the reflux temperature (145° C.) for 2 hours. The resultant solution was concentrated in vacuo, and purged with toluene to afford a brown oil.

後処理

  1. temperatureThe reaction mixture was heated to, and
  2. concentrationThe resultant solution was concentrated in vacuo
  3. custompurged with toluene
  4. customto afford a brown oil

出典と根拠

ORDレコード
ord-e24861fab953455c9357084dcf0bbd5a
出典データセット
uspto-grants-2010_07
特許番号
US07749997B2

反応ノート

読み込み中…