1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 58830628、化合物

HRID 2353387ノート

反応式

HRID 2353387 の反応式
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([C:9]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:10][OH:11])=[C:4](F)[CH:3]=1.N12CCCN=C1CCCCC2>O1CCCC1>[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]2[C:9]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[N:10][O:11][C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 135961542HCID 135961542、化合物2 回

生成物 1

HCID 58830628HCID 58830628、化合物収率 27.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of Z/E (4-bromo-2,5-difluorophenyl)(4-pyridinyl)methanone oxime (Intermediate 5, 124 mg) and 1,8-diazabicyclo[5.4.0]undec-7-ene (40 mg) in tetrahydrofuran (1.5 ml) was heated at 150° C. in a microwave oven for 30 min. The solvent was removed under vacuum and the residue was triturated with a small quantity of methanol to give the title compound as a cream coloured solid (32 mg).

後処理

  1. customThe solvent was removed under vacuum
  2. customthe residue was triturated with a small quantity of methanol

出典と根拠

ORDレコード
ord-bd9b56dcae3a4bc181fb96dd567d537d
出典データセット
uspto-grants-2010_07
特許番号
US07750026B2

反応ノート

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