Triethylamine → 2-(2,5-dioxopyrrolidin-1-yl)ethyl Methanesulfonate

HRID 2353482ノート

反応式

HRID 2353482 の反応式
[OH:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[CH2:7][CH2:6][C:5]1=[O:10].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C1COCC1>[CH3:18][S:19]([O:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[CH2:7][CH2:6][C:5]1=[O:10])(=[O:21])=[O:20]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 236334N-[2-Hydroxyethyl]succinimide

生成物 1

HCID 100822242-(2,5-dioxopyrrolidin-1-yl)ethyl Methanesulfonate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The N-(2-hydroxyethyl)succinimide (Aldrich, 0.19 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

出典と根拠

ORDレコード
ord-377c69ae356f42ff83e7b22408d457a9
出典データセット
uspto-grants-2010_07
特許番号
US07750039B2

反応ノート

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