Benzenesulfonyl chloride → 2-Bromobenzoic acid 2-phenylsulfonylhydrazide

HRID 235361

反応式

HRID 235361 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:6][NH2:7])=[O:5].[C:12]1([S:18](Cl)(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[C:12]1([S:18]([NH:7][NH:6][C:4](=[O:5])[C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=2[Br:1])(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 7369Benzenesulfonyl chlorideHCID 1014602-Bromobenzohydrazide

生成物 1

HCID 77099642-Bromobenzoic acid 2-phenylsulfonylhydrazide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 2-bromobenzoic acid hydrazide (132 g) in pyridine (1.2 L) cooled to about 10° C. with an ice bath, was added benzensulfonyl chloride (78.3 ml). After complete addition, the reaction was stirred at ambient temperature for four hours, and then poured into ice-hydrochloric acid to precipitate a yellow solid, 135 g. The material was recrystallized from isopropanol to yield 125 g of 2-bromobenzoic acid 2-phenylsulfonylhydrazide, m.p.=154°-156° C.

後処理

  1. additionAfter complete addition
  2. customto precipitate a yellow solid, 135 g
  3. customThe material was recrystallized from isopropanol

出典と根拠

ORDレコード
ord-e09030c4e2f54fa49fa0eeada62fb2ad
出典データセット
uspto-grants-1997_01
特許番号
US05597842

関連ノート

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