2-Aminothiazole → tert-butyl N-[(2-methylpropan-2-yl)oxycarbonyl]-N-(1,3-thiazol-2-yl)carbamate
反応式
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.C(=O)(OC(C)(C)C)[O:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=O>CN(C1C=CN=CC=1)C.C1COCC1>[CH3:15][C:12]([O:11][C:9]([N:1]([C:2]1[S:3][CH:4]=[CH:5][N:6]=1)[C:9](=[O:8])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:8])([CH3:13])[CH3:14]参加物
5
実験手順
A solution of 2-aminothiazole (5 g, 0.05 mol), (2-methylpropan-2-yl)oxycarbonyl tert-butyl carbonate (27.8 g, 0.15 mol) and DMAP (100 mg) in THF (100 mL) was stirred at reflux overnight. The mixture was allowed to cool and concentrated in vacuo. The residue was chromatographed on silica, eluting with 8% ethyl acetate in hexane, to give the desired material as a white solid (12 g).
後処理
- temperatureat reflux overnight
- temperatureto cool
- concentrationconcentrated in vacuo
- customThe residue was chromatographed on silica
- washeluting with 8% ethyl acetate in hexane
出典と根拠
- ORDレコード
- ord-457ab25f55914f61a52cbae8174eabb4
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07750003B2
反応ノート
読み込み中…