Sodium Iodide → (S)-4-(2-Chloro-6-(iodomethyl)pyrimidin-4-YL)-3-methylmorpholine
反応式
[I-:1].[Na+].[Cl:3][C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][C@@H:11]2[CH3:16])[CH:7]=[C:6]([CH2:17]OS(C)(=O)=O)[N:5]=1>C(Cl)Cl>[Cl:3][C:4]1[N:5]=[C:6]([CH2:17][I:1])[CH:7]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][C@@H:11]2[CH3:16])[N:9]=1参加物
4
反応条件
- 温度
- 40 °C
実験手順
Sodium iodide (1.006 ml, 24.61 mmol) was added to 2-chloro-4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonyloxymethyl)pyrimidine (1.584 g, 4.92 mmol) in DCM at RT. The resulting solution was refluxed at 40° C. for 18 hours. The reaction mixture was diluted with DCM and washed with water. The organic layer was dried (MgSO4), filtered and evaporated to afford the desired product (1.596 g).
後処理
- washwashed with water
- dry with materialThe organic layer was dried (MgSO4)
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-0e4f3feb1fa84b7eb8d1ccc07623834a
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07750003B2
反応ノート
読み込み中…