Hydrochloric Acid → HCID 68443745、化合物
反応式
[ClH:1].Br[C:3]1[CH:13]=[C:12]([O:14]C(=O)C)[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6][C:7](=[O:9])[CH3:8].[OH-].[Na+]>O1CCOCC1>[Cl:1][C:3]1[CH:13]=[C:12]([OH:14])[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6][C:7](=[O:9])[CH3:8]参加物
5
実験手順
10% Aq. hydrochloric acid (2.5 ml) was added to a solution of 2-chloro-4-acetoxy-5-methoxy-N-acetyl-benzylamine 2 (0.45 g, 1.66 mmol) in dioxane (15 ml) and the mixture was refluxed for 2 hours. After cooling, the solvent was reduced under vacuum and the residue was basified with 10% aq. NaOH. The resulting solid was collected by filtration, washed with cold water and dried to furnish the title compound as white solid in quantitative yield.
後処理
- temperaturethe mixture was refluxed for 2 hours
- temperatureAfter cooling
- filtrationThe resulting solid was collected by filtration
- washwashed with cold water
- customdried
出典と根拠
- ORDレコード
- ord-cfc2a0eca8d645b7b35dc1b311f6dead
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07750049B2
反応ノート
読み込み中…