HCID 11410496、化合物 → HCID 11248845、化合物
反応式
Br[C:2]1[CH:3]=[CH:4][C:5]([O:34][CH3:35])=[C:6]([S:8]([N:11]([CH:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][NH:22][C:23]([NH:25][C:26]3[CH:31]=[C:30]([CH3:32])[N:29]=[C:28]([CH3:33])[CH:27]=3)=[O:24])[CH2:16][CH2:15]2)[CH2:12][CH3:13])(=[O:10])=[O:9])[CH:7]=1>CO.[Pd]>[CH3:32][C:30]1[CH:31]=[C:26]([NH:25][C:23](=[O:24])[NH:22][CH2:21][CH2:20][N:17]2[CH2:18][CH2:19][CH:14]([N:11]([CH2:12][CH3:13])[S:8]([C:6]3[CH:7]=[CH:2][CH:3]=[CH:4][C:5]=3[O:34][CH3:35])(=[O:10])=[O:9])[CH2:15][CH2:16]2)[CH:27]=[C:28]([CH3:33])[N:29]=1参加物
4
実験手順
A suspension of 5-bromo-N-(1-{2-[3-(2,6-dimethyl-pyridin-4-yl)-ureido]-ethyl}-piperidin-4-yl)-N-ethyl-2-methoxy-benzenesulfonamide (Example 99, 30 mg, 0.05 mmol) and Pd—C (10%, 20 mg) in MeOH (10 mL) is stirred under hydrogen atmosphere for 15 h. The catalyst is filtered off and the reaction mixture evaporated to provide the title compound.
後処理
- filtrationThe catalyst is filtered off
- custom