Hydrochloric Acid → (2E)-3-[5-({(3R)-1-[2-(dimethylamino) benzyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]acrylic acid

HRID 2354089ノート

反応式

HRID 2354089 の反応式
[CH3:1][N:2]([CH3:28])[C:3]1[CH:27]=[CH:26][CH:25]=[CH:24][C:4]=1[CH2:5][N:6]1[CH2:10][CH2:9][C@@H:8]([NH:11][C:12]2[N:13]=[CH:14][C:15](/[CH:18]=[CH:19]/[C:20]([O:22]C)=[O:21])=[N:16][CH:17]=2)[CH2:7]1.[OH-].[Na+].Cl>CO>[CH3:28][N:2]([CH3:1])[C:3]1[CH:27]=[CH:26][CH:25]=[CH:24][C:4]=1[CH2:5][N:6]1[CH2:10][CH2:9][C@@H:8]([NH:11][C:12]2[N:13]=[CH:14][C:15](/[CH:18]=[CH:19]/[C:20]([OH:22])=[O:21])=[N:16][CH:17]=2)[CH2:7]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67128674methyl (2E)-3-[5-({(3R)-1-[2-(dimethylamino)benzyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]acrylate

生成物 1

HCID 67128945(2E)-3-[5-({(3R)-1-[2-(dimethylamino) benzyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]acrylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
55 °C

実験手順

To a solution of methyl (2E)-3-[5-({(3R)-1-[2-(dimethylamino) benzyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]acrylate (235 mg) in MeOH (1.9 mL) was added 1N NaOH aq. (1.2 mL), which was stirred at 55° C. for 1 hour. To the reaction mixture was added 1N—HCl aq. (1.2 mL), and evaporated in vacuo to give a crude (2E)-3-[5-({(3R)-1-[2-(dimethylamino)benzyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]acrylic acid as, a brown solid (0.310 mg). This was used next reaction without purification.

後処理

  1. customevaporated in vacuo

出典と根拠

ORDレコード
ord-0cd47b884fa8490099b9663803b4e17e
出典データセット
uspto-grants-2010_07
特許番号
US07750155B2

反応ノート

読み込み中…