Bromine → 4-Bromo-3-fluorophenacyl bromide
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[F:11].[Br:12]Br>C(Cl)(Cl)Cl>[Br:12][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[C:3]([F:11])[CH:4]=1)=[O:10]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a 0° C. solution containing 2.4 g of 1-(4-bromo-3-fluorophenyl)ethanone (11.1 mmols) in 56 mL of CHCl3 was added dropwise 0.57 mL of bromine (11.1 mmols). The reaction was stirred at 0° C. for three hours and then allowed to warm to ambient temperature. The reaction mixture was quenched with 10 mL of saturated aqueous Na2S2O3. The layers were separated, and the organics were dried over MgSO4, filtered through a frit, and concentrated to a yellow solid which was used without further purification.
後処理
- temperatureto warm to ambient temperature
- customThe reaction mixture was quenched with 10 mL of saturated aqueous Na2S2O3
- customThe layers were separated
- dry with materialthe organics were dried over MgSO4
- filtrationfiltered through a frit
- concentrationconcentrated to a yellow solid which
- customwas used without further purification
出典と根拠
- ORDレコード
- ord-c3f57d5dc47945f581eb4020fab1a10b
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07749998B2
反応ノート
読み込み中…