p-Toluenesulfonic acid → 2-(4-Bromophenyl)benzothiazole
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].[Br:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=1.CC1C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[Br:9][C:10]1[CH:17]=[CH:16][C:13]([C:14]2[S:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=2)=[CH:12][CH:11]=1参加物
5
実験手順
2-aminothiophenol 9.01 g (72 mmole), 4-bromobenzaldehyde 16 g (87 mmole), and 2.8 g of PTSA (14 mmole) was stirred in 150 ml of Toluene, the reaction mixture was then heated to reflux for 16 hours, after cooling, the reaction mixture was extracted with water, and then the organic layer was evaporated to dry, the residue was then recrystallized with acetone to get 13.43 g of product (yield=64.3%).
後処理
- temperaturethe reaction mixture was then heated
- temperatureto reflux for 16 hours
- temperatureafter cooling
- extractionthe reaction mixture was extracted with water
- customthe organic layer was evaporated
- customto dry
- customthe residue was then recrystallized with acetone
出典と根拠
- ORDレコード
- ord-7b6fb0299e9b4caf970788efb9b36d15
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07754348B2
反応ノート
読み込み中…