Lithium Hydroxide → 4-Amino-2-(methylthio)pyrimidine-5-carboxylic acid

HRID 2354614ノート

反応式

HRID 2354614 の反応式
[NH2:1][C:2]1[C:7]([C:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([S:11][CH3:12])[N:3]=1.[OH-].[Li+]>CO.O>[NH2:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[C:4]([S:11][CH3:12])[N:3]=1

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 225621764-Amino-2-methylsulfanyl-5-pyrimidinecarboxylate

生成物 1

HCID 221347384-Amino-2-(methylthio)pyrimidine-5-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

4-Amino-2-methylmercaptopyrimidine-5-carboxylate (1.5 g, 7 mmol) was suspended in the solution of lithium hydroxide (340 mg, 14 mmol) in methanol (10 mL) and water (5 mL) and stirred at 60° C. over night. Solid was filtered out and filtrate was collected. Solvent was removed under reduce pressure. Residue was dissolved in water and was neutralized by acetic acid till pH˜5. White solid thus formed was filtered out and dried in vacuo (0.72 g, 55%).

後処理

  1. filtrationSolid was filtered out
  2. customfiltrate was collected
  3. customSolvent was removed
  4. dissolutionResidue was dissolved in water
  5. customWhite solid thus formed
  6. filtrationwas filtered out
  7. customdried in vacuo (0.72 g, 55%)

出典と根拠

ORDレコード
ord-bd662edec37b4806b34560e6ab585f28
出典データセット
uspto-grants-2010_07
特許番号
US07754726B2

反応ノート

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