2-Pyridineethanamine → HCID 16036094、化合物

HRID 2354822

反応式

HRID 2354822 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH2:9].[F:10][C:11]([F:36])([F:35])[C:12]1[CH:34]=[CH:33][CH:32]=[CH:31][C:13]=1[C:14]([N:16]1[CH2:21][CH2:20][N:19]([C:22]2[N:27]=[N:26][C:25]([C:28](Cl)=[O:29])=[CH:24][CH:23]=2)[CH2:18][CH2:17]1)=[O:15]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:28]([C:25]1[N:26]=[N:27][C:22]([N:19]2[CH2:18][CH2:17][N:16]([C:14](=[O:15])[C:13]3[CH:31]=[CH:32][CH:33]=[CH:34][C:12]=3[C:11]([F:36])([F:35])[F:10])[CH2:21][CH2:20]2)=[CH:23][CH:24]=1)=[O:29]

参加物

3

反応物 2

HCID 759192-PyridineethanamineHCID 865972306-{4-[2-(Trifluoromethyl)benzoyl]piperazin-1-yl}pyridazine-3-carbonyl chloride

生成物 1

HCID 16036094HCID 16036094、化合物

実験手順

Following the procedure of Example 28, making variations only as required to use 2-pyridin-2-ylethylamine in place of 2-aminopyridine to react with 6-[4-(2-trifluoromethyl-benzoyl)piperazin-1-yl]pyridazine-3-carbonyl chloride, the title compound was obtained as a white powder (30%). m.p. 151-154° C. 1H NMR (300 MHz, DMSO-d6) δ 9.07, 8.78, 8.43, 7.99-7.61, 7.52, 7.34, 3.79-3.60, 3.35-3.14. MS (ES+) m/z 485.3 (M+1).

出典と根拠

ORDレコード
ord-3b47a47c8f8441e19fdc8e829324b75f
出典データセット
uspto-grants-2010_07
特許番号
US07754711B2

関連ノート

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