Tert-butyl 3,4-dihydroxypyrrolidine-1-carboxylate → 1,1-Dimethylethyl N,N-bis(2-oxoethyl)carbamate

HRID 2354884ノート

反応式

HRID 2354884 の反応式
I([O-])(=O)(=O)=O.[Na+].[C:7]([O:11][C:12]([N:14]1[CH2:18][CH:17]([OH:19])[CH:16]([OH:20])[CH2:15]1)=[O:13])([CH3:10])([CH3:9])[CH3:8]>O.C1COCC1>[C:7]([O:11][C:12](=[O:13])[N:14]([CH2:18][CH:17]=[O:19])[CH2:15][CH:16]=[O:20])([CH3:10])([CH3:8])[CH3:9]

参加物

5

反応物 2

HCID 13329884Tert-butyl 3,4-dihydroxypyrrolidine-1-carboxylateHCID 23667635Sodium periodate

生成物 1

HCID 135745471,1-Dimethylethyl N,N-bis(2-oxoethyl)carbamate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Sodium periodate (20.31 g, 94.96 mmol) in H2O (118 mL) was added to a cooled solution of 3,4-dihydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (19.3 g, 94.6 mmol) in THF (158 mL) over a 30 minute period. The resulting white suspension was allowed to stir at room temperature for 3 h. The suspension was filtered and the filtrate concentrated under vacuum to remove the THF. The resulting aqueous solution was used directly in the next reaction.

後処理

  1. filtrationThe suspension was filtered
  2. concentrationthe filtrate concentrated under vacuum
  3. customto remove the THF
  4. customThe resulting aqueous solution was used directly in the next reaction

出典と根拠

ORDレコード
ord-d5257c58c1784844bea6b37a89cafe0f
出典データセット
uspto-grants-2010_07
特許番号
US07754712B2

反応ノート

読み込み中…