Sodium Hydroxide → HCID 6483399、化合物

HRID 2354999ノート

反応式

HRID 2354999 の反応式
[OH-].[Na+].C[O:4][C:5](=[O:17])[C:6]1[CH:11]=[C:10]([OH:12])[CH:9]=[C:8]([O:13][CH:14]([CH3:16])[CH3:15])[CH:7]=1>CO>[OH:12][C:10]1[CH:9]=[C:8]([O:13][CH:14]([CH3:16])[CH3:15])[CH:7]=[C:6]([CH:11]=1)[C:5]([OH:17])=[O:4]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 23072925Methyl 3-hydroxy-5-isopropoxybenzoate

生成物 1

HCID 6483399HCID 6483399、化合物収率 87%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

After adding 10 ml of 4N aqueous sodium hydroxide solution to a solution of the 3.0 g (14.3 mmol) of 5-hydroxy-3-isopropoxybenzoic acid methyl ester obtained in Production Example 59 in methanol (50 ml), the mixture was stirred at room temperature for 12 hours. The reaction mixture was concentrated under reduced pressure, and then saturated aqueous ammonium chloride was added, extraction was performed with chloroform, and the organic layer was dried and then concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (chloroform:methanol=50:1) to obtain 2.44 g of 5-hydroxy-3-isopropoxybenzoic acid (yield: 87%) as a white solid.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionsaturated aqueous ammonium chloride was added
  3. extractionextraction
  4. customthe organic layer was dried
  5. concentrationconcentrated under reduced pressure
  6. customThe obtained residue was purified by silica gel chromatography (chloroform:methanol=50:1)

出典と根拠

ORDレコード
ord-82d1369eb524469fa37866580e09a85c
出典データセット
uspto-grants-2010_07
特許番号
US07754743B2

反応ノート

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