Sodium Carbonate → HCID 57652834、化合物

反応式

Br[C:2]1[S:6][C:5]([NH2:7])=[N:4][N:3]=1.[Br:8][C:9]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:10]=1[O:11][C@H:12]1[CH2:16][CH2:15][NH:14][CH2:13]1.C(=O)([O-])[O-].[Na+].[Na+]>CCO>[Br:8][C:9]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:10]=1[O:11][C@H:12]1[CH2:16][CH2:15][N:14]([C:2]2[S:6][C:5]([NH2:7])=[N:4][N:3]=2)[CH2:13]1

参加物

反応条件

温度: 90 °C

実験手順

A mixture of 5-bromo-1,3,4-thiadiazol-2-amine (1 g, 5.6 mmol), (3S)-3-(2-bromo-5-fluorophenoxy)pyrrolidine (1.6 g, 6.1 mmol) and sodium carbonate (1.2 g, 11 mmol) in EtOH (11 mL) was degassed with nitrogen for 5 mins. The mixture was then heated at 90° C. for 3 h. The mixture was then cooled to room temperature and filtered. The solvent was evaporated and diluted with water (50 mL). The solid precipitate was filtered and washed with water followed by Et2O to afford the title product.