Lithium hydroxide, monohydrate → 3-((6-Aminopyridin-3-yl)carbamoyl)-4-methylbenzoic acid

反応式

[NH2:1][C:2]1[N:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[C:13]([CH:18]=[CH:19][C:20]=2[CH3:21])[C:14]([O:16]C)=[O:15])=[O:10])=[CH:4][CH:3]=1.O.[OH-].[Li+]>O1CCCC1.O>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[C:13]([CH:18]=[CH:19][C:20]=2[CH3:21])[C:14]([OH:16])=[O:15])=[O:10])=[CH:4][CH:3]=1

参加物

実験手順

To methyl 3-((6-aminopyridin-3-yl)carbamoyl)-4-methylbenzoate (0.11 g, 0.39 mmol) dissolved in tetrahydrofuran (1.5 mL) was added a solution of lithium hydroxide, monohydrate (24 mg, 0.58 mmol) in water (1.5 mL). The reaction mixture was stirred at RT for 4 h. THF was removed in vacuo and to the aqueous layer was added 2N HCl until pH 4-5. The precipitate formed was collected by filtration, washed with water, dried to give 3-((6-aminopyridin-3-yl)carbamoyl)-4-methylbenzoic acid as a tan solid, MS (ESI, pos. ion) m/z: 272.1 (M+1).