Water → Methyl [(1H-indol-5-yl)oxy]acetate

HRID 2355257ノート

反応式

HRID 2355257 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:18][C:19]([O:21][CH2:22]C)=[O:20].O>CC(C)=O.C(Cl)Cl>[NH:7]1[C:8]2[C:4](=[CH:3][C:2]([O:1][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:10][CH:9]=2)[CH:5]=[CH:6]1

参加物

7

反応物 4

HCID 962WaterHCID 7748Ethyl bromoacetateHCID 10796Cesium carbonateHCID 160545-Hydroxyindole

生成物 1

HCID 59808925Methyl [(1H-indol-5-yl)oxy]acetate

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 6344Dichloromethane溶媒

実験手順

A suspension of 5-hydroxyindole (5.00 g; 37.6 mmol), caesium carbonate (26.9 g, 82.6 mmol) and ethyl bromoacetate (4.60 g, 30.0 mmol) in 100 ml acetone is stirred for 18 hours at ambient temperature. Then the reaction mixture is combined with water and DCM. The phases are separated and the aqueous phase is extracted with DCM. The combined phases are dried on sodium sulphate and freed from the solvent in vacuo.

後処理

  1. customThe phases are separated
  2. extractionthe aqueous phase is extracted with DCM
  3. customThe combined phases are dried on sodium sulphate

出典と根拠

ORDレコード
ord-fcd5193f926f4eea8bbee093f190ba5e
出典データセット
uspto-grants-2010_07
特許番号
US07754756B2

反応ノート

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