1,1'-Carbonyldiimidazole → 1-Benzylimidazolidin-2-one

HRID 23558

反応式

HRID 23558 の反応式
[CH2:1]([NH:8][CH2:9][CH2:10][NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:12](N1C=CN=C1)(N1C=CN=C1)=[O:13]>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[CH2:9][CH2:10][NH:11][C:12]1=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 77801N-Benzylethylenediamine

生成物 1

HCID 2314031-Benzylimidazolidin-2-one収率 49.2%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of N-benzylethylenediamine (6.0 g, 40 mmol) in toluene (50 ml) at 0° C. was added 1,1′-carbonylbis-1H-imidazole (7.8 g, 48 mmol). After stirring the mixture at room temperature overnight, the reaction mixture was washed with water, 5% aqueous citric acid solution and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The residue was recrystallized with warm ethyl acetate and filtered off to give 1-benzylimidazolidin-2-one (3.47 g).

後処理

  1. washthe reaction mixture was washed with water, 5% aqueous citric acid solution and brine
  2. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customevaporated under reduced pressure
  5. customThe residue was recrystallized with warm ethyl acetate
  6. filtrationfiltered off

出典と根拠

ORDレコード
ord-25f7d1db2d0b40efa6b910d5b1689781
出典データセット
uspto-grants-2005_02
特許番号
US06852744B2

関連ノート

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