1,1'-Carbonyldiimidazole → 1-Benzylimidazolidin-2-one
反応式
[CH2:1]([NH:8][CH2:9][CH2:10][NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:12](N1C=CN=C1)(N1C=CN=C1)=[O:13]>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[CH2:9][CH2:10][NH:11][C:12]1=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
To a solution of N-benzylethylenediamine (6.0 g, 40 mmol) in toluene (50 ml) at 0° C. was added 1,1′-carbonylbis-1H-imidazole (7.8 g, 48 mmol). After stirring the mixture at room temperature overnight, the reaction mixture was washed with water, 5% aqueous citric acid solution and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The residue was recrystallized with warm ethyl acetate and filtered off to give 1-benzylimidazolidin-2-one (3.47 g).
後処理
- washthe reaction mixture was washed with water, 5% aqueous citric acid solution and brine
- dry with materialThe organic phase was dried over anhydrous magnesium sulfate
- filtrationfiltered
- customevaporated under reduced pressure
- customThe residue was recrystallized with warm ethyl acetate
- filtrationfiltered off
出典と根拠
- ORDレコード
- ord-25f7d1db2d0b40efa6b910d5b1689781
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06852744B2
反応ノート
読み込み中…