2(1h)-Quinazolinone,3,4-dihydro-8-methoxy-3-[1-(phenylmethyl)-4-piperidinyl]- → 8-Methoxy-3-piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one

HRID 2355945ノート

反応式

HRID 2355945 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:23][C:22]3[C:17](=[C:18]([O:24][CH3:25])[CH:19]=[CH:20][CH:21]=3)[NH:16][C:15]2=[O:26])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH3:25][O:24][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:17]=1[NH:16][C:15](=[O:26])[N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[CH2:23]2

参加物

4

反応物 1

HCID 211021562(1h)-Quinazolinone,3,4-dihydro-8-methoxy-3-[1-(phenylmethyl)-4-piperidinyl]-

生成物 1

HCID 183210478-Methoxy-3-piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one収率 93%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

3-(1-Benzyl-piperidin-4-yl)-8-methoxy-3,4-dihydro-1H-quinazolin-2-one (100 mg, 0.28 mmol) in methanol (5 mL) was flushed with nitrogen, and treated with palladium on charcoal (10%, 10 mg). The flask was flushed with hydrogen and allowed to stir under an atmosphere of hydrogen overnight. The reaction was flushed with nitrogen, filtered through celite, and concentrated. Column chromatography gave 68 mg (93%) of the desired material. LC/MS: tR=1.11 min, 262.23 (MH)+.

後処理

  1. customThe flask was flushed with hydrogen
  2. customThe reaction was flushed with nitrogen
  3. filtrationfiltered through celite
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-70af1f74f4184cbbb3f68dd6797d8dfd
出典データセット
uspto-grants-2010_07
特許番号
US07754732B2

反応ノート

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