Methyl 4-(4-tert-butyl-1-cyclohexen-1-yl)benzoate → HCID 22730084、化合物
反応式
[C:1]([CH:5]1[CH2:10][CH2:9][C:8]([C:11]2[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=2)=[CH:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[C:1]([CH:5]1[CH2:6][CH2:7][CH:8]([C:11]2[CH:12]=[CH:13][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:19][CH:20]=2)[CH2:9][CH2:10]1)([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
A room temperature mixture of Example 5B (230 mg, 0.84 mmol) and 10% Pd/C (100 mg) in ethyl acetate (5 mL) was stirred under a hydrogen atmosphere for 3 hours, filtered through a pad of silica gel (10 g) with diethyl ether (10 mL), and concentrated to provide the desired product as a ˜2:1 mixture of diastereomers. MS (DCI) m/e 275 (M+H)+.
後処理
- filtrationfiltered through a pad of silica gel (10 g) with diethyl ether (10 mL)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-f30e19aaf47440f08eab52a2623df621
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07754886B2
反応ノート
読み込み中…