1,3-Propanediol → 4-(1,3,2-Dioxaborinan-2-yl)benzoic acid

HRID 2356076ノート

反応式

HRID 2356076 の反応式
[OH:1][B:2]([OH:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[CH2:13](O)[CH2:14][CH2:15]O>C1(C)C=CC=CC=1>[O:1]1[CH2:15][CH2:14][CH2:13][O:12][B:2]1[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 104421,3-PropanediolHCID 3121834-Carboxyphenylboronic Acid

生成物 1

HCID 145278654-(1,3,2-Dioxaborinan-2-yl)benzoic acid

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 4-(dihydroxyboryl)benzoic acid (30.00 g, 181 mmol) and 1,3-propanediol (15.20 g, 200 mmol) in toluene (750 mL) at 140° C. was stirred for 6 hours while collecting the water removed by azeotrope formation. The mixture was concentrated to provide the desired product.

後処理

  1. customwhile collecting the water
  2. customremoved by azeotrope formation
  3. concentrationThe mixture was concentrated

出典と根拠

ORDレコード
ord-8a80a9a9a3624b2cac0e71a14c74c267
出典データセット
uspto-grants-2010_07
特許番号
US07754886B2

反応ノート

読み込み中…