p-Chlorothiophenol → 2-[(4-Chlorophenyl)thio]ethanamine
反応式
[Na].Br.Br[CH2:4][CH2:5][NH2:6].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([SH:14])=[CH:10][CH:9]=1>C(O)C>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([S:14][CH2:4][CH2:5][NH2:6])=[CH:10][CH:9]=1参加物
5
反応条件
- 温度
- 75 °C
実験手順
A solution of sodium metal (22.5 mg, 0.98 mmol) in ethanol (2.0 mL) was treated with 2-bromoethylamine hydrobromide (100.0 mg, 0.49 mmol) and 4-chlorobenzenethiol (71.0 mg, 0.49 mmol), heated to 75° C. for 18 hours, and concentrated. The concentrate was partitioned between water (2.0 mL) and diethyl ether (5.0 mL) and the organic phase was dried (MgSO4), filtered, and concentrated to provide the desired product. MS (DCI) m/e 188 (M+H)+.
後処理
- concentrationconcentrated
- customThe concentrate was partitioned between water (2.0 mL) and diethyl ether (5.0 mL)
- dry with materialthe organic phase was dried (MgSO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-e19874b790974d4abc4aac9364f5c8ae
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07754886B2
反応ノート
読み込み中…