Methylamine → 1-Methylamino-2-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]-cyclobut-1-ene-3,4-dione

HRID 235663

反応式

HRID 235663 の反応式
CO[C:3]1[C:6](=O)[C:5](=[O:8])[C:4]=1[O:9]C.[Br:11][C:12]1[CH:13]=[C:14]([CH3:23])[C:15]([CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])=[N:16][CH:17]=1.[CH3:24][NH2:25]>CCOCC.C(O)C.C(Cl)(Cl)Cl>[CH3:24][NH:25][C:6]1[C:5](=[O:8])[C:4](=[O:9])[C:3]=1[NH:22][CH2:21][CH2:20][CH2:19][CH2:18][C:15]1[C:14]([CH3:23])=[CH:13][C:12]([Br:11])=[CH:17][N:16]=1

参加物

7

反応物 3

HCID 6329MethylamineHCID 1232273-Cyclobutene-1,2-dione, 3,4-dimethoxy-HCID 130942724-(5-Bromo-3-methyl-2-pyridinyl)butylamine

生成物 1

HCID 145374531-Methylamino-2-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]-cyclobut-1-ene-3,4-dione

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒HCID 3283Diethyl Ether溶媒HCID 6212Chloroform溶媒

実験手順

Treatment of 1,2-dimethoxycyclobut-1-ene-3,4-dione with 4-(5-bromo-3-methylpyrid-2-yl)-butylamine in dry ether at 0° C. followed by methylamine in ethanol and chromatography in chloroform on silica gel yielded 1-methylamino-2-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]-cyclobut-1-ene-3,4-dione m.p. 190°-191° C. after recrystallisation from acetonitrile.

後処理

  1. customat 0° C.

出典と根拠

ORDレコード
ord-2ed6ac3865a1489eb5ee6e582db217fa
出典データセット
uspto-grants-1987_02
特許番号
US04640926

関連ノート

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