Nitric Acid → 3-Nitro-4-(propan-2-yl)aniline
反応式
[CH:1]([C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[N+:11]([O-])([OH:13])=[O:12]>S(=O)(=O)(O)O>[CH:1]([C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][C:5]=1[N+:11]([O-:13])=[O:12])([CH3:3])[CH3:2]参加物
4
反応条件
- 温度
- 0 °C
実験手順
25 g (185 mmol) 4-isopropyl-aniline were dissolved in to 260 ml conc. sulfuric acid and treated at −5° C. with 17.9 g nitric acid (65%). After stirring the mixture at 0° C. for 0.5 h, the reaction mixture was poured on ice water and the precipitating product collected via filtration and dried. The resulting 23.8 g product were essentially pure and were used for the subsequent step without further purification.
後処理
- additionthe reaction mixture was poured on ice water
- filtrationthe precipitating product collected via filtration
- customdried
- customwere used for the subsequent step without further purification
出典と根拠
- ORDレコード
- ord-979ce5355aca43b4bc65aacd6856db4a
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07759379B2
反応ノート
読み込み中…