Acetyl chloride → N-Acetyl-L-serine methyl ester

HRID 235710

反応式

HRID 235710 の反応式
Cl.[CH3:2][O:3][C:4](=[O:9])[C@H:5]([CH2:7][OH:8])[NH2:6].C(N(CC)CC)C.[C:17](Cl)(=[O:19])[CH3:18]>C(Cl)(Cl)Cl>[C:17]([NH:6][C@H:5]([C:4]([O:3][CH3:2])=[O:9])[CH2:7][OH:8])(=[O:19])[CH3:18]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 2723730L-Serine, methyl ester, hydrochloride (1:1)

生成物 1

HCID 7010549N-Acetyl-L-serine methyl ester

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a suspension of about 46.57 g of L-serine methyl ester hydrochloride in about 3 liters of chloroform was added about 84 ml of triethylamine. This mixture was stirred until solution was complete, then about 21 ml of acetyl chloride was added dropwise. The mixture was then stirred under argon for about 2 days and the chloroform removed under reduced pressure. The residue was suspended in ethanol, filtered through a sintered glass funnel and the ethanol removed, giving about 49 g of the desired title compound [α]D26 =+36°±1° (CHCl3, 1.039%).

後処理

  1. stirringThe mixture was then stirred under argon for about 2 days
  2. customthe chloroform removed under reduced pressure
  3. filtrationfiltered through a sintered glass funnel
  4. customthe ethanol removed

出典と根拠

ORDレコード
ord-a2cbcbd39a6b4bd0989d6e6ebf5761a8
出典データセット
uspto-grants-1987_02
特許番号
US04640913

関連ノート

読み込み中…