Chlorotrimethylsilane → HCID 10345215、化合物

HRID 2357476ノート

反応式

HRID 2357476 の反応式
[CH3:1][N:2]([CH3:33])[C:3]1([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([N:12]2[CH2:16][CH2:15][CH:14]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][CH:18]=3)[CH2:13]2)=[O:11])[CH2:5][CH2:4]1.C[Si](C)(C)[Cl:36]>CC(CC)=O>[ClH:36].[CH3:33][N:2]([CH3:1])[C:3]1([C:26]2[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([N:12]2[CH2:16][CH2:15][CH:14]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][CH:18]=3)[CH2:13]2)=[O:11])[CH2:5][CH2:4]1

参加物

4

反応物 2

HCID 6397ChlorotrimethylsilaneHCID 103452162-[4-dimethylamino-4-(4-fluorophenyl)cyclohexyl]-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone

生成物 1

HCID 10345215HCID 10345215、化合物収率 93%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

The polar diastereoisomer of 2-[4-dimethylamino-4-(4-fluorophenyl)cyclohexyl]-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone (329 mg, 0.73 mmole) was dissolved in ethyl methyl ketone (10 ml) and trimethylchlorosilane (0.14 ml, 1.1 mmole) was added, and the whole was stirred for 1.5 hours at RT. The precipitated hydrochloride was isolated in a yield of 93% (329 mg) and had an m.p. of 170°-177° C. (Example 41).

出典と根拠

ORDレコード
ord-04675c1e51e341bfa472b72f82349792
出典データセット
uspto-grants-2010_07
特許番号
US07759385B2

反応ノート

読み込み中…