Chlorotrimethylsilane → 2-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)piperidine-1-yl]-ethanone hydrochloride

HRID 2357490ノート

反応式

HRID 2357490 の反応式
[CH3:1][N:2]([CH3:33])[C:3]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([N:12]2[CH2:17][CH2:16][CH2:15][CH:14]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[NH:20][CH:19]=3)[CH2:13]2)=[O:11])[CH2:5][CH2:4]1.[Cl:34][Si](C)(C)C>CC(CC)=O>[ClH:34].[CH3:33][N:2]([CH3:1])[C:3]1([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([N:12]2[CH2:17][CH2:16][CH2:15][CH:14]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[NH:20][CH:19]=3)[CH2:13]2)=[O:11])[CH2:5][CH2:4]1

参加物

4

反応物 2

HCID 6397ChlorotrimethylsilaneHCID 99825912-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)piperidine-1-yl]-ethanone

生成物 1

HCID 99825902-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)piperidine-1-yl]-ethanone hydrochloride収率 65%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

2-(4-dimethylamino-4-phenylcyclohexyl)-1-[3-(1H-indol-3-yl)piperidine-1-yl]-ethanone (66 mg, 0.148 mmole) was dissolved in ethyl methyl ketone (4 ml) and chlorotrimethylsilane (0.03 ml, 0.23 mmole) was added. After 1 hour the hydrochloride was isolated as a colourless solid in a yield of 65% (46 mg) (Example 53). A melting point could not be determined. The hydrochloride was obtained as a diastereoisomer mixture.

出典と根拠

ORDレコード
ord-a67bb9b81fed40a6a581fee77f122379
出典データセット
uspto-grants-2010_07
特許番号
US07759385B2

反応ノート

読み込み中…