Aluminium lithium hydride → (R)-4-Benzyl-3-methylmorpholine
反応式
[CH2:1]([N:8]1[C@H:13]([CH3:14])[CH2:12][O:11][CH2:10][C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[CH2:1]([N:8]1[CH2:9][CH2:10][O:11][CH2:12][C@H:13]1[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
(R)-4-Benzyl-5-methylmorpholin-3-one (5.05 g, 24.6 mmol) was dissolved in THF (12.3 mL) before lithium aluminum hydride (1.87 g, 49.2 mmol) was added and the mixture stirred at RT for 1 h. The reaction mixture was quenched with ethyl acetate before a few drops of ammonium chloride was added. The colorless oil was filtered, washed with dichloromethane, concentrated, and purified by flash chromatography to give the title compound. MS (ES+): 192(M+H)+.
後処理
- additionwas added
- customThe reaction mixture was quenched with ethyl acetate before a few drops of ammonium chloride
- additionwas added
- filtrationThe colorless oil was filtered
- washwashed with dichloromethane
- concentrationconcentrated
- custompurified by flash chromatography
出典と根拠
- ORDレコード
- ord-5f408e81e4434b42857c65d9b0c11eec
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07759337B2
反応ノート
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