Methanol → HCID 178497700、化合物

反応式

[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:13]=[C:14]([CH:18]=[CH:19][C:20]=3[CH3:21])[C:15]([OH:17])=[O:16])=[CH:9][CH:10]=2)[CH:5]=[N:4][N:3]=1.S(Cl)(Cl)=O.[CH3:26]O>>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:13]=[C:14]([CH:18]=[CH:19][C:20]=3[CH3:21])[C:15]([O:17][CH3:26])=[O:16])=[CH:9][CH:10]=2)[CH:5]=[N:4][N:3]=1

参加物

反応物 3

HCID 887Methanol

HCID 24386Thionyl Chloride

HCID 178425877HCID 178425877、化合物

生成物 1

HCID 178497700HCID 178497700、化合物

反応条件

温度: 50 °C

実験手順

3-(1-Hydroxyphthalazin-6-yl)-4-methylbenzoic acid (2.71 g, 9.67 mmol) was suspended in methanol (96.7 mL), thionyl chloride (2.12 mL, 29.0 mmol) was added and the mixture was stirred at 50° C. for 1.5 h and at RT overnight. The mixture was concentrated to give the title compound. MS (ES+): 295(M+H)+.

後処理

concentrationThe mixture was concentrated

出典と根拠

ORDレコード: ord-026ba7a5091345a19e969aeee4fc0e49
出典データセット: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07759337B2

反応ノート

読み込み中…