HCID 178518953、化合物 → aza-THIP

HRID 2357681ノート

反応式

HRID 2357681 の反応式
C([N:8]1[CH2:13][CH2:12][C:11]2[C:14]([OH:17])=[N:15][NH:16][C:10]=2[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[NH:16]1[C:10]2[CH2:9][NH:8][CH2:13][CH2:12][C:11]=2[C:14]([OH:17])=[N:15]1

参加物

4

反応物 1

HCID 178518953HCID 178518953、化合物

生成物 1

HCID 178518952aza-THIP

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 6-benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-ol (2.00 g, 8.72 mmol) and palladium on carbon (0.200 g, 1.88 mmol, Aldrich) in MeOH (100 mL) was stirred under H2 atmosphere for 48 h. The mixture was filtered through Celite® and the filter cake was washed with MeOH. The mixture was concentrated in vacuo. The filter cake was washed with water and the filtrate was concentrated in vacuo. Both fractions contained the title compound. MS (ESI, pos. ion) m/z: 140 (M+1).

後処理

  1. filtrationThe mixture was filtered through Celite®
  2. washthe filter cake was washed with MeOH
  3. concentrationThe mixture was concentrated in vacuo
  4. washThe filter cake was washed with water
  5. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-0a62205f17014cc2b18655f26601f55c
出典データセット
uspto-grants-2010_07
特許番号
US07759337B2

反応ノート

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