(Diethylamino)sulfur trifluoride → HCID 59389401、化合物
反応式
CCN(S(F)(F)[F:7])CC.O[CH:11]([C:13]1[CH:31]=[C:16]2[C:17]([C:23]3[CH:24]([CH3:30])[CH2:25][C:26](=[O:29])[NH:27][N:28]=3)=[CH:18][CH:19]=[C:20]([O:21][CH3:22])[N:15]2[N:14]=1)[CH3:12]>C(Cl)(Cl)Cl>[F:7][CH:11]([C:13]1[CH:31]=[C:16]2[C:17]([C:23]3[CH:24]([CH3:30])[CH2:25][C:26](=[O:29])[NH:27][N:28]=3)=[CH:18][CH:19]=[C:20]([O:21][CH3:22])[N:15]2[N:14]=1)[CH3:12]参加物
4
反応条件
- 温度
- 0 °C
実験手順
DAST (51.2 mg) was added dropwise to a solution of the compound of Example 238 (80.0 mg) in chloroform (10 mL) at 0° C. and the mixture was stirred at 0° C. for 30 min. The reaction was quenched by adding a saturated aqueous sodium bicarbonate solution and the reaction mixture was extracted with chloroform (30 mL). The extract was washed with water and saturated brine and dried over anhydrous sodium sulfate. The dried extract was concentrated and purified by silica gel column chromatography (hexane:ethyl acetate=1:4) to afford the title compound as a pale yellow powder (30.6 mg).