HCID 59389336、化合物 → HCID 59389321、化合物
反応式
[OH:1][CH2:2][C:3]1[C:4]2[N:5]([N:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=2)[C:6]([CH2:9][O:10][CH3:11])=[CH:7][CH:8]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:11][O:10][CH2:9][C:6]1[N:5]2[N:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=[C:4]2[C:3]([CH:2]=[O:1])=[CH:8][CH:7]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
Activated manganese dioxide (20.0 g) was added to a solution of the compound of Example 326 (6.00 g) in chloroform (120 mL). The reaction mixture was stirred at 50° C. for 5 hours. Subsequently, the mixture was filtered through Celite. The filtrate was concentrated to afford the title compound as a pale yellow powder (5.74 g).
後処理
- filtrationSubsequently, the mixture was filtered through Celite
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-e8fb9fb736c44da28e5a8e133c142576
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07763617B2
反応ノート
読み込み中…