O-Xylene → (1,1-dimethylethyl) 3-[[5-methyl-6-[4-(1,2,3,4-tetrahydro-1,8-naphthyridin-7-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(phenylmethoxy)carbonyl]alaninate

反応式

Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH2:9][C@@H:10]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[NH:11][C:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:13])[C:3]=1[CH3:29].[NH:30]1[CH2:35][CH2:34][CH:33]([C:36]2[N:45]=[C:44]3[C:39]([CH2:40][CH2:41][CH2:42][NH:43]3)=[CH:38][CH:37]=2)[CH2:32][CH2:31]1.C1(C)C(C)=CC=CC=1.C(=O)(O)[O-].[Na+]>C(N(C(C)C)CC)(C)C.O.C(OCC)(=O)C.CO.C(N(CC)CC)C.ClCCl.C(OCC)(=O)C>[NH:43]1[C:44]2[C:39](=[CH:38][CH:37]=[C:36]([CH:33]3[CH2:34][CH2:35][N:30]([C:2]4[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH2:9][C@@H:10]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[NH:11][C:12]([O:14][CH2:15][C:16]5[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=5)=[O:13])[C:3]=4[CH3:29])[CH2:31][CH2:32]3)[N:45]=2)[CH2:40][CH2:41][CH2:42]1