Hydrogen Bromide → 4-(2-Bromo-2,2-difluoro-ethyl)-pyrrolidin-2-one

HRID 2358228ノート

反応式

HRID 2358228 の反応式
[F:1][C:2]([F:10])=[CH:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1.[BrH:11]>O>[Br:11][C:2]([F:10])([F:1])[CH2:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 17948959HCID 17948959、化合物

生成物 1

HCID 589112584-(2-Bromo-2,2-difluoro-ethyl)-pyrrolidin-2-one収率 49%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a 50 ml three necked flask fitted with a magnetic stirrer, under inert atmosphere, 0.1 g of 4-(2,2-difluoro-vinyl)-pyrrolidin-2-one a5 (0.6 mmol) is heated in HBr (62% w/w in H2O, 10 ml) for 0.75 h at reflux. The reaction mixture is cooled down to room temperature, diluted with water and extracted with CH2Cl2 (3 times), dried over MgSO4, filtered and concentrated in vacuo to afford 0.076 g of 4-(2-bromo-2,2-difluoro-ethyl)-pyrrolidin-2-one a6 (49%).

後処理

  1. temperatureat reflux
  2. extractionextracted with CH2Cl2 (3 times)
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-14a74e31c8124ad5afc98a56028857ab
出典データセット
uspto-grants-2010_07
特許番号
US07763644B2

反応ノート

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