4-Bromo-7a-methyl-hexahydro-indene-1,5-dione → 4-Allyloxy-7a-methyl-hexahydro-indene-1,5-dione

HRID 2358270ノート

反応式

HRID 2358270 の反応式
Br[CH:2]1[C:10](=[O:11])[CH2:9][CH2:8][C:7]2([CH3:12])[CH:3]1[CH2:4][CH2:5][C:6]2=[O:13]>C(O)C=C>[CH2:10]([O:11][CH:2]1[C:10](=[O:11])[CH2:9][CH2:8][C:7]2([CH3:12])[CH:3]1[CH2:4][CH2:5][C:6]2=[O:13])[CH:9]=[CH2:8]

参加物

3

反応物 1

HCID 141132994-Bromo-7a-methyl-hexahydro-indene-1,5-dione

生成物 1

HCID 684575234-Allyloxy-7a-methyl-hexahydro-indene-1,5-dione

試薬・触媒・溶媒 1

HCID 7858Allyl Alcohol溶媒

実験手順

To the stirred suspension of 4-bromo-7a-methyl-hexahydro-indene-1,5-dione 1 (prepared according to the procedure described in J. Org. Chem. 2001, 66, 626.) (2.44 g, 10 mmol), molecular sieves of 4 Å (2.5 g) and silica gel (2.5 g) in allyl alcohol (20 mL) was added Ag2O (2.55 g, 11 mmol) at room temperature. The reaction mixture was stirred at room temperature in the dark for 8 h. The reaction mixture was filtered through a mixture of Celite® and silica gel. The solvent was removed under reduced pressure to yield the title compound as a crude yellow oil.

後処理

  1. customprepared
  2. filtrationThe reaction mixture was filtered through a mixture of Celite® and silica gel
  3. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-86f823d3f7ed40d1b438dae46a6f298b
出典データセット
uspto-grants-2010_07
特許番号
US07763648B2

反応ノート

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