Dimethylformamide → 2-Hydroxy-4-methoxybenzoyl chloride

HRID 2358311

反応式

HRID 2358311 の反応式
[OH:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:15])=O.CN(C=O)C>ClCCCl>[OH:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:15])=[O:5]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 752314-Methoxysalicylic Acid

生成物 1

HCID 231185592-Hydroxy-4-methoxybenzoyl chloride収率 99.1%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

To a solution of 2-hydroxy-p-anisic acid (0.2 g, 1.2 mmol) in DCE (8 mL) was added thionyl chloride (0.13 mL, 1.8 mmol) and a drop of DMF. After stirring at room temperature for 4.5 h the reaction mixture was concentrated and azeotroped several times with benzene to give the acid chloride 123 as a white solid (222 mg).

後処理

  1. concentrationwas concentrated
  2. customazeotroped several times with benzene

出典と根拠

ORDレコード
ord-bfaddc38c3fc471697e8ad06e946ba5b
出典データセット
uspto-grants-2010_07
特許番号
US07763614B2

関連ノート

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