Toluene → N-[4-(1-Aminoethyl)-2-fluoro-6-vinylphenyl]methanesulfonamide
反応式
C(OC(=O)[NH:7][CH:8]([C:10]1[CH:15]=[C:14]([CH:16]=[CH2:17])[C:13]([NH:18][S:19]([CH3:22])(=[O:21])=[O:20])=[C:12]([F:23])[CH:11]=1)[CH3:9])(C)(C)C.C1(C)C=CC=CC=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:7][CH:8]([C:10]1[CH:15]=[C:14]([CH:16]=[CH2:17])[C:13]([NH:18][S:19]([CH3:22])(=[O:21])=[O:20])=[C:12]([F:23])[CH:11]=1)[CH3:9]参加物
5
実験手順
[1-(3-fluoro-4-methanesulfonylamino-5-vinyl phenyl)ethyl]carbamic acid tert-butyl ester (0.06 mmol, 20.2 mg) was dissolved in methylene chloride, 5˜6 drops of CF3COOH were added. A reaction mixture was stirred for 12 hr. A toluene was added. The reaction mixture was concentrated in vacuo to yield brownish syrup (20.8 mg, 100.0%).
後処理
- concentrationThe reaction mixture was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-cb073f7511d04f34b05d8bfb1cf903e4
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07763657B2
反応ノート
読み込み中…