2-(Trifluoromethyl)aniline → 4-Iodo-2-(trifluoromethyl)aniline

HRID 2358385ノート

反応式

HRID 2358385 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH2:9].[I:12]Cl>C(Cl)Cl>[I:12][C:7]1[CH:6]=[CH:5][C:4]([NH2:9])=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:8]=1

参加物

4

反応物 2

HCID 69222-(Trifluoromethyl)anilineHCID 24640Iodine chloride

生成物 1

HCID 32894324-Iodo-2-(trifluoromethyl)aniline収率 42.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-Trifluoromethylphenylamine (30 mg, 0.21 mmol) and ICl (1.1 eq, 0.24 mmol, 38.97 mg) were added into methylene chloride. The reaction mixture was stirred for 12 hr. The reaction mixture was purified according to step 2 of Example 8 to give a title compound (25.6 mg, 42.48%).

後処理

  1. customThe reaction mixture was purified

出典と根拠

ORDレコード
ord-88b17524ca914712b38405136e8f2f3f
出典データセット
uspto-grants-2010_07
特許番号
US07763657B2

反応ノート

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