Dimethylformamide → 4-Amino-3-(trifluoromethyl)benzonitrile

HRID 2358386ノート

反応式

HRID 2358386 の反応式
I[C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.[CH3:13][N:14](C=O)C>[C-]#N.[C-]#N.[Zn+2].C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([C:13]#[N:14])=[CH:3][C:4]=1[C:9]([F:12])([F:11])[F:10]

参加物

5

反応物 2

HCID 6228DimethylformamideHCID 32894324-Iodo-2-(trifluoromethyl)aniline

生成物 1

HCID 27794884-Amino-3-(trifluoromethyl)benzonitrile収率 99.28%

試薬・触媒・溶媒 2

HCID 11186Zinc cyanide (Zn(CN)2)触媒2 回HCID 178418397HCID 178418397、化合物触媒2 回

実験手順

4-Iodo-2-trifluoromethylphenylamine (50 mg, 0.17 mmol), Zn(CN)2 (0.88 eq, 0.15 mmol, 18.00 mg), and Pd(PPh3)4 (0.1 eq, 0.02 mmol, 19.64 mg) were added in DMF. Zn(CN)2 (0.88 eq, 0.15 mmol, 18.00 mg) and Pd(PPh3)4 (0.1 eq, 0.02 mmol, 19.64 mg) were added into the reaction mixture. The reaction mixture was stirred for 12 hr. The reaction mixture was purified according to step 1 of Example 8 to give a title product as a yellow solid (31.4 mg, 99.28%).

後処理

  1. customThe reaction mixture was purified

出典と根拠

ORDレコード
ord-6b2ad0d85656467c995735799c585ae7
出典データセット
uspto-grants-2010_07
特許番号
US07763657B2

反応ノート

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