Iodine → HCID 68454898、化合物
反応式
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][NH:7][C:8]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:14][CH:13]=2)=[O:9])=[CH:4][C:3]=1[F:24].[I:25]I>[O-]S([O-])(=O)=O.[Ag+].[Ag+].C(O)C>[NH2:1][C:2]1[C:23]([I:25])=[CH:22][C:5]([CH2:6][NH:7][C:8]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([CH3:19])([CH3:20])[CH3:21])=[CH:14][CH:13]=2)=[O:9])=[CH:4][C:3]=1[F:24]参加物
5
実験手順
To the 50 ml of round bottom flask were put 1-(4-amino-3-fluoro-benzyl)-3-(4-t-butyl-benzyl)-urea (0.25 g, 0.76 mmol) and Ag2SO4 (1.1 eq, 0.26 g) and then cooled to 0° C. And to this mixture was poured 20 ml ethanol and added I2 (1.0 eq, 0.193 g) portionwise and stirred for 3 hours at room temperature. After confirming the completion of the reaction with TLC, the reaction mixture was filtered through celite and concentrated under reduced pressure.