Acetonitrile → N-(7-Chloro-1,8-naphthyridin-2-yl)-3-dimethylaminobenzamide

HRID 235846

反応式

HRID 235846 の反応式
[CH3:1][N:2]([CH3:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=O.[NH2:13][C:14]1[CH:23]=[CH:22][C:21]2[C:16](=[N:17][C:18]([Cl:24])=[CH:19][CH:20]=2)[N:15]=1.C(#N)C>O>[Cl:24][C:18]1[N:17]=[C:16]2[C:21]([CH:22]=[CH:23][C:14]([NH:13][C:6](=[O:8])[C:5]3[CH:9]=[CH:10][CH:11]=[C:3]([N:2]([CH3:1])[CH3:12])[CH:4]=3)=[N:15]2)=[CH:20][CH:19]=1

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 668373-(Dimethylamino)benzoic acidHCID 851997-Chloro-1,8-naphthyridin-2-amine

生成物 1

HCID 20217506N-(7-Chloro-1,8-naphthyridin-2-yl)-3-dimethylaminobenzamide収率 63.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
4 °C

実験手順

The procedure is similar to that described in Example 1, but starting with 3-dimethylaminobenzoic acid (6.6 g), N,N'-carbonyldiimidazole (6.5 g) and 2-amino-7-chloro-1,8-naphthyridine (5.4 g). The product produced by precipitation in water (9 g; m.p. 212° C.) is dissolved in boiling acetonitrile (400 cc). After 3 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with acetonitrile (3×20 cc) and dried at 40° C. under reduced pressure (0.067 kPa). N-(7-Chloro-1,8-naphthyridin-2-yl)-3-dimethylaminobenzamide (6.2 g) is produced, m.p. 215° C.

後処理

  1. dissolutionis dissolved
  2. customthe crystallised solid is separated by filtration
  3. washwashed with acetonitrile (3×20 cc)
  4. customdried at 40° C. under reduced pressure (0.067 kPa)

出典と根拠

ORDレコード
ord-7e60164d16154487bf86938c319458e4
出典データセット
uspto-grants-1987_02
特許番号
US04642308

関連ノート

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