3-Chloroaniline → 3-(3-Chlorophenylamino)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carbonitrile

HRID 2358859

反応式

HRID 2358859 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[O:9]=[C:10]1[N:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:14]2[S:22][C:23]([C:32]#[N:33])=[C:24](NC3C=CC=CC=3)[C:13]=2[CH:12]=[CH:11]1>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:24]2[C:13]3[CH:12]=[CH:11][C:10](=[O:9])[N:15]([C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=4)[C:14]=3[S:22][C:23]=2[C:32]#[N:33])[CH:6]=[CH:7][CH:8]=1

参加物

3

反応物 2

HCID 79323-ChloroanilineHCID 684576476-Oxo-7-phenyl-3-phenylamino-6,7-dihydro-thieno[2,3-b]pyridine-2-carbonitrile

生成物 1

HCID 684555623-(3-Chlorophenylamino)-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carbonitrile

実験手順

The title compound was prepared from 3-chloroaniline (115 mg, 0.9 mmol) following the method described for the compound of Example 18 to give the product as a pale yellow solid (125 mg). δH (CDCl3) 7.67-7.58 (3H, m), 7.44-7.41 (2H, m), 7.39 (1H, d, J 9.7 Hz), 7.31-7.26 (1H, m), 7.12-7.09 (1H, m), 7.04 (1H, t, J 2.0 Hz), 6.95-6.92 (1H, m), 6.57 (1H, d, J 9.7 Hz), 6.54 (1H, bs). LCMS (ES+) 378 (M+H)+ 35Cl, 380 (M+H)+ 37Cl.

出典と根拠

ORDレコード
ord-7bba5550f5954ae9a3a3794e1e0ea306
出典データセット
uspto-grants-2010_07
特許番号
US07763729B2

関連ノート

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