Epichlorohydrin → 2-Methyl-4-(2,3-epoxypropyl)benzaldehyde

HRID 235923ノート

反応式

HRID 235923 の反応式
[CH2:1]([CH:3]1[O:5][CH2:4]1)Cl.[CH3:6][C:7]1[CH:14]=[C:13](O)[CH:12]=[CH:11][C:8]=1[CH:9]=[O:10]>[OH-].[Na+]>[CH3:6][C:7]1[CH:14]=[C:13]([CH2:1][CH:3]2[O:5][CH2:4]2)[CH:12]=[CH:11][C:8]=1[CH:9]=[O:10]

参加物

4

反応物 2

HCID 7835EpichlorohydrinHCID 4581854-Hydroxy-2-methylbenzaldehyde

生成物 1

HCID 200299172-Methyl-4-(2,3-epoxypropyl)benzaldehyde収率 71.4%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

反応条件

温度
55 °C

実験手順

To epichlorohydrin (20 g., 0.216 mole) heated at 55° C. is added dropwise a solution of 2-methyl-4-hydroxybenzaldehyde (9.0 g., 0.066 mole) in 2.5N sodium hydroxide solution (40 ml.). After the addition, the solution is allowed to stir an additional 3 hours at 55° C. and then at room temperature overnight. The oil is distilled to give 8.3 g of 2-methyl-4-(2,3-epoxypropyl)benzaldehyde, m.p. 160°-170° C. at 1 mm. Hg.

後処理

  1. additionAfter the addition
  2. customat room temperature
  3. customovernight
  4. distillationThe oil is distilled

出典と根拠

ORDレコード
ord-37cb86dad2664b549ca28236e9aa0d5c
出典データセット
uspto-grants-1987_02
特許番号
US04642311

反応ノート

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