ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Diisopropylethylamine → HCID 44553916、化合物

HRID 2359412
ノート
印刷プレビュー

反応式

HRID 2359412 の反応式
CC1(C)[O:6][CH:5]([CH2:7][O:8][C:9]2[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=2)[CH2:4][O:3]1.[F:17][C:18]([F:39])([F:38])[C:19]1[CH:20]=[C:21]([C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[C:28]([C:35](O)=[O:36])[CH:29]=[CH:30][CH:31]=3)[N:26]=2)[CH:22]=[CH:23][CH:24]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN1C(=O)CCC1.O>[OH:6][CH:5]([CH2:4][OH:3])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([NH:13][C:35]([C:28]2[CH:29]=[CH:30][CH:31]=[C:32]3[C:27]=2[N:26]=[C:25]([C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([C:18]([F:39])([F:17])[F:38])[CH:20]=2)[CH:34]=[CH:33]3)=[O:36])=[CH:14][CH:15]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 575815714-((2,2-Dimethyl-1,3-dioxolan-4-yl)methoxy)anilineHCID 58154625HCID 58154625、化合物

生成物 1

HCID 44553916HCID 44553916、化合物収率 79.2%

試薬・触媒・溶媒

2
HCID 962Water溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

To a mixture of 4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)aniline (167 mg, 0.750 mmol), 2-(3-(trifluoromethyl)phenyl)quinoline-8-carboxylic acid (159 mg, 0.500 mmol), HATU (285 mg, 0.75 mmol) in NMP (5 mL) was added DIPEA (173 μL, 1.0 mmol). The reaction was stirred for 72 hours at room temperature, water (5 mL) was added and the resulting precipitates were collected by filtration and recrystallized from ethanol. The yellow solid was treated with a mixture of 1:3 6N HCl/Dioxane (8 mL) overnight. The mixture was concentrated to dryness, triturated with water, collected by filtration, washed with water and dried to obtain N-(4-(2,3-dihydroxypropoxy)phenyl)-2-(3-(trifluoromethyl)phenyl)quinoline-8-carboxamide (191 mg, 79% yield). MS (ESI) calcd for C26H21F3N2O4 (m/z): 482.15. found: 483 [M+1].

後処理

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration
  3. customrecrystallized from ethanol
  4. additionThe yellow solid was treated with a mixture of 1:3 6N HCl/Dioxane (8 mL) overnight
  5. concentrationThe mixture was concentrated to dryness
  6. customtriturated with water
  7. filtrationcollected by filtration
  8. washwashed with water
  9. customdried

出典と根拠

ORDレコード
ord-ccd84f44314d48aeb98ad1fbbc66aab5
出典データセット
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08685970B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート